l -Ficolin binding and lectin pathway activation by acetylated low-density lipoprotein
نویسندگان
چکیده
منابع مشابه
Regulation of high density lipoprotein binding activity of aortic endothelial cells by treatment with acetylated low density lipoprotein.
High density lipoprotein (HDL) binding to human fibroblasts and arterial smooth muscle cells is up-regulated when sterol is delivered to cells in the form of nonlipoprotein cholesterol or low density lipoprotein (LDL). Results from the present study show that the HDL binding activity of aortic endothelial cells is up-regulated when cholesterol in the form of acetylated LDL (AcLDL) is delivered ...
متن کاملA macrophage receptor that recognizes oxidized low density lipoprotein but not acetylated low density lipoprotein.
The formation of cholesterol-loaded macrophage foam cells in arterial tissue may occur by the uptake of modified lipoproteins via the scavenger receptor pathway. The macrophage scavenger receptor, also called the acetylated low density lipoprotein (Ac-LDL) receptor, has been reported to recognize Ac-LDL as well as oxidized LDL species such as endothelial cell-modified LDL (EC-LDL). We now repor...
متن کاملInteractions of ficolin and mannose-binding lectin with fibrinogen/fibrin augment the lectin complement pathway.
Ficolin and mannose-binding lectin (MBL) are animal lectins that are involved in innate immunity by initiating the lectin complement pathway. Here, we report that interactions between these lectins and fibrinogen/fibrin augment the lectin pathway. An ELISA revealed that recombinant mouse ficolin A (rFcnA), rMBL-A and rMBL-C bind to fibrinogen in a dose-dependent manner. Affinity Western blottin...
متن کاملLow invasiveness of pneumococcal serotype 11A is linked to ficolin-2 recognition of O-acetylated capsule epitopes and lectin complement pathway activation.
BACKGROUND The divergent epidemiological behavior of Streptococcus pneumoniae serotypes suggests that serotype-specific features such as capsule O-acetylation influence the propensity of a strain to cause invasive pneumococcal disease (IPD). We hypothesize that innate host factors mediate the observed negative association between IPD and the serotype 11A (ST11A) capsule O-acetyltransferase gene...
متن کاملThe Effect of ? -Tocopherol on Copper Binding to Low Density Lipoprotein
The oxidative modification of low density lipoprotein (LDL) may play an important role in atherogenesis. Antioxidants that can prevent LDL oxidation may act as antiatherogens. Our understanding of the mechanism of LDL oxidation and factors that determine its susceptibility to oxidation is still incomplete. Copper is a candidate for oxidizing LDL in atherosclerotic lesions. The binding of copper...
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ژورنال
عنوان ژورنال: Clinical & Experimental Immunology
سال: 2007
ISSN: 0009-9104
DOI: 10.1111/j.1365-2249.2007.03538.x